RAF-IN-10n

SKU: orb1223541

Description

A highlt potent and selective BRAF/CRAF inhibitor with IC50 of 24/25 nM, respectively; displays moderate selectivity over p38α (IC50=216 nM) and CAMKII (IC50=822 nM), high selectivity over CDK2, CDK4, PKCa, IKKb, JNK1, MK2, PKA, Src, MKK6, PLK1, p70S6K, PI3 Ka, and PDK1 (IC50>2 uM).

Key Properties

• CAS Number: 950736-05-7
• MW: 515.529
• Purity: >98% (HPLC)
• Formula: C₂₉H₂₄F₃N₅O
• SMILES: O=C(NC1=CC=CC(C2=CC=NC3=C(C4=CC=C(CN(C)C)C=C4)C=NN23)=C1)C5=CC=CC(C(F)(F)F)=C5
• Target: Raf
• Solubility: DMSO: ≥ 53 mg/mL

Bioactivity

• In Vitro:
  B-Raf IN 1 (Compound 10n) inhibits WM 266-4 and HT29 cells with IC50s of 0.92 and 0.78 μM, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

B-RAF IN 1

Quick Database Links

Gene Symbol

Raf