Radotinib dihydrochloride

SKU: orb3211520

Description

Radotinib (IY-5511) dihydrochloride is an orally bioavailable and brain-penetrant selective tyrosine kinase Bcr-Abl1 inhibitor with an IC50 of 34 nM. It exhibits antiprion and antitumor activities by inhibiting tumor cell proliferation, inducing cell cycle arrest, and triggering apoptosis. Radotinib dihydrochloride is applicable in research on chronic myeloid leukemia, multiple myeloma, other tumors, and prion-related neurodegenerative diseases.

Key Properties

• CAS Number: 926037-85-6
• MW: 603.43
• Formula: C₂₇H₂₃Cl₂F₃N₈O
• SMILES: O=C(C1=CC=C(C)C(NC2=NC(C3=NC=CN=C3)=CC=N2)=C1)NC4=CC(C(F)(F)F)=CC(N5C=NC(C)=C5)=C4.Cl.Cl
• Target: STAT,Bcr-Abl,JAK,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

STAT,Bcr-Abl,JAK,Apoptosis