Radioprotectin-1

SKU: orb1309172

Description

Radioprotectin-1 is a potent and selective agonist for the LPA2 receptor (EC₅₀ = 25 nM for murine LPA2). It has demonstrated radioprotective and radiomitigative efficacy in research models, making it a valuable tool for studying lysophosphatidic acid signaling in radiation biology and related fields.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1622006-09-0
• MW: 486.92
• Purity: 99.43% (May vary between batches)
• Formula: C₂₃H₁₉ClN₂O₆S
• SMILES: OC(=O)c1cc(Cl)ccc1S(=O)(=O)NCCCCN1C(=O)c2cccc3cccc(C1=O)c23
• Target: LPA Receptor,LPL Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.21 mM);DMSO:100 mg/mL (205.37 mM)

Bioactivity

• Target IC50:
  LPA2 subtype (murine):（EC50）25 nM
• In Vivo:
  In C57BL/6 female mice, Radioprotectin-1 (0.1 and 0.3 mg/kg; s.c.) decreases the mortality in models of the hematopoietic and gastrointestinal acute radiation syndrome.
• In Vitro:
  In MEF and IEC-6 cells expressing LPA2, Radioprotectin-1 (0, 0.1, 0.3, 1.0, and 3 μM) effectively reduces apoptosis induced by gamma-irradiation and the radiomimetic chemotherapeutic Adriamycin.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-chloro-2-[4-(1,3-dioxobenzo[de]isoquinolin-2-yl)butylsulfamoyl]benzoic acid, LPAReceptor, LPA Receptor, LPA2, murine LPA2 subtype, Radioprotectin-1

Compound Identifiers

PubChem CID

77461257