Radicicol

SKU: orb1706736

Description

Radicicol

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 12772-57-5
• MW: 364.78
• Formula: C₁₈H₁₇ClO₆
• SMILES: C[C@@H]1C[C@@H]2[C@H](O2)/C=C\C=C\C(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
• Target: Parasite,Antibacterial,Antifungal,Antibiotic,NOS,NF-κB,p38 MAPK,HSP
• Solubility: DMSO:80 mg/mL (219.31 mM)

Bioactivity

• Target IC50:
  HSP90:1 μM
• In Vivo:
  Methods: Radicicol (20 mg/kg/60 mg/kg, intraperitoneal injection, 2 doses, 1 h apart) was administered to mice to observe its inhibitory effect on (I/R) injury in mice. Results: Radicicol has a renal Protective effect, improves renal ischemia-reperfusion (I/R) injury, and increases renal HSP70 mRNA and protein in mice with renal injury.
• In Vitro:
  Radicicol inhibits PDK1 activity with an IC50 value of 230 mM and PDK3 with an IC50 value of 400 μM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Monorden, HSP90, Radicicol

Compound Identifiers

PubChem CID

6323491