Raddeanin A

SKU: orb1303621

Description

Raddeanin A is a triterpenoid saponin derived from Cyperus japonicus, functioning as a histone deacetylase inhibitor and a potent inducer of immunogenic cell death. It exhibits robust anti-tumor and anti-angiogenic activities, making it a valuable tool for cancer research in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 89412-79-3
• MW: 897.10
• Purity: 99.94%
• Formula: C₄₇H₇₆O₁₆
• SMILES: [H][C@@]1(O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@@]2([H])O[C@@H]2[C@@H](O)[C@@H](O)CO[C@@]2([H])O[C@H]2CC[C@@]3(C)[C@@]([H])(CC[C@]4(C)[C@]3([H])CC=C3[C@]5([H])CC(C)(C)CC[C@@]5(CC[C@@]43C)C(O)=O)C2(C)C)O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
• Target: Apoptosis,HDAC
• Solubility: DMSO:82.50 mg/mL (91.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.00 mg/mL (2.23 mM)

Bioactivity

• In Vivo:
  METHODS: Raddeanin A (NSC-382873) (1, 2, and 4 mg/kg, intraperitoneally or intratumorally) was used to treat mice bearing a subcutaneous xenograft model of MC38 melanoma cells to investigate the effects of Raddeanin A on the immune control of tumor growth in vivo. RESULTS Raddeanin A caused considerable suppression of tumor size and weight in MC38 tumor-bearing mice; Raddeanin A effectively suppressed tumor growth in mice bearing B16 melanoma; however, intratumoral treatment with Raddeanin A did not significantly alter mouse body weight.
• In Vitro:
  METHODS: Raddeanin A (NSC-382873) (1, 2, 5 μM, 20 hours) treated B16-HMGB1-Gluc and MC38-HMGB1-Gluc cells, and measured HMGB1-Gluc luciferase activity and extracellular ATP levels. RESULTS Raddeanin A induced a significant increase in HMGB1-Gluc activity and ATP release in both B16 and MC38 cells in a dose-dependent manner.

Storage & Handling

• Storage: store under nitrogen,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cancer, Anemodeanin A, Apoptosis, Cholangiocarcinoma, HDAC, Inhibitor, inhibit, NSC 382873, NSC382873, NSC-382873, osteosarcoma, Raddeanin A, Raddeanin R3, prostate

Compound Identifiers

PubChem CID

174742