RAD51-IN-1

SKU: orb1298225

Description

Rad51-in-1 is a potent small molecule inhibitor derived from B02 that effectively targets the Rad51 protein. It is utilized in cancer research to study DNA repair mechanisms, demonstrating activity in both cellular assays and in vivo models of tumorigenesis.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2101739-18-6
• MW: 373.83
• Purity: 99.87% (May vary between batches)
• Formula: C₂₂H₁₆ClN₃O
• SMILES: Clc1ccc(Cn2c(\C=C\c3cccnc3)nc3ccccc3c2=O)cc1
• Target: DNA/RNA Synthesis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.35 mM);DMSO:27.5 mg/mL (73.56 mM)

Bioactivity

• In Vitro:
  RAD51-IN-1(10μM) decreases the ratio of RAD51 positive cells/cH2AX postive cells in MDA-MB-231 cell exposure to 6 Gy irradiation. RAD51-IN-1 (10μM) significantly inhibits DNA damage induced RAD51 foci formation with 6 Gy irradiation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNASynthesis, DNA Synthesis, DNA damage, chemotherapy, cancer, Inhibitor, inhibit, RAD51 IN 1, RAD51IN1, RAD-51-IN-1, RAD51-IN-1, RAD51, RNASynthesis, RNA Synthesis, tumor cell

Compound Identifiers

PubChem CID

53245568