(rac)-Talazoparib

SKU: orb2945848

Description

(rac)-Talazoparib is a potent, orally bioavailable PARP1/2 inhibitor with low nanomolar Ki values. It effectively blocks cellular PARylation, induces DNA damage accumulation, and inhibits proliferation in BRCA-deficient cell lines. This compound has also demonstrated in vivo antitumor efficacy in mouse xenograft models.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1207454-56-5
• MW: 380.351
• Formula: C₁₉H₁₄F₂N₆O
• SMILES: O=C1NN=C2C=3C(=CC(F)=CC13)NC(C4=CC=C(F)C=C4)C2C5=NC=NN5C
• Target: PARP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

135743681