(Rac)-SIS3 free base

SKU: orb1708519

Description

SIS3 free base is a selective inhibitor of Smad3 phosphorylation, effectively blocking TGF-β1-induced myofibroblast differentiation. This mechanism supports its use in vitro for studying fibrotic pathways and has shown promise in vivo models of pulmonary and renal fibrosis.

Research Area

Stem Cell & Developmental Biology

Images & Validation

−

Key Properties

−

CAS Number	1009104-85-1
MW	453.53
Formula	C₂₈H₂₇N₃O₃
SMILES	COc1cc2CCN(Cc2cc1OC)C(=O)\C=C\c1c(-c2ccccc2)n(C)c2ncccc12
Target	TGF-beta/Smad

Storage & Handling

−

Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

10138988 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols