(Rac)-SIS3 free base

SKU: orb1708519

Description

SIS3 free base is a selective inhibitor of Smad3 phosphorylation, effectively blocking TGF-β1-induced myofibroblast differentiation. This mechanism supports its use in vitro for studying fibrotic pathways and has shown promise in vivo models of pulmonary and renal fibrosis.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1009104-85-1
• MW: 453.53
• Formula: C₂₈H₂₇N₃O₃
• SMILES: COc1cc2CCN(Cc2cc1OC)C(=O)\C=C\c1c(-c2ccccc2)n(C)c2ncccc12
• Target: TGF-beta/Smad

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

10138988