(Rac)-PROTAC PARP/EGFR ligand 1

SKU: orb3132655

Description

(Rac)-PROTAC PARP/EGFR ligand 1 is a compound that includes ligands for target proteins PARP and EGFR, along with a PROTAC linker that recruits E3 ligases such as VHL, CRBN, MDM2, and IAP. It is utilized in the synthesis of PROTAC DP-C-4, a dual CRBN-based PROTAC designed for the concurrent degradation of EGFR and PARP.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2935073-36-0
• MW: 1020.52
• Formula: C₅₃H₅₆ClF₂N₉O₈
• SMILES: O=C1NN=C(C=2C=CC=CC12)CC3=CC=C(F)C(=C3)C(=O)N4CCN(C(=O)CCCCCNC(=O)C(NC(=O)CCCCCOC5=CC=6C(=NC=NC6NC7=CC=C(F)C(Cl)=C7)C=C5OC)COCC#C)CC4
• Target: Target Protein Ligand-Linker Conjugates

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Target Protein Ligand-Linker Conjugates