(Rac)-PF-4136309（1341224-83-6 Free base)

SKU: orb2279153

Description

PF-4136309 (INCB8761) is a potent, selective, and orally bioavailable CCR2 antagonist with an IC50 of 5.2 nM against the human receptor. It has been widely used in preclinical research to investigate the role of CCR2 in inflammatory diseases and cancer metastasis, demonstrating efficacy in both in vitro assays and in vivo animal models.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 857679-55-1
• MW: 568.59
• Formula: C₂₉H₃₁F₃N₆O₃
• SMILES: O=C(NC1=NC=C2C=CC(=CC2=C1)C=3C=NN(C3)C)C=4C=CN=C(C4)N5CCN(C)CC5
• Target: Others,CCR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

132056570