(Rac)-MGV354

SKU: orb1309176

Description

(Rac)-MGV354 is the racemic form of MGV354, a potent soluble guanylate cyclase (sGC) activator with EC50 values below 0.5 nM in CHO cells and 5 nM in GTM-3E cells. This compound is a valuable research tool for investigating sGC signaling pathways in cardiovascular and pulmonary disease models, both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1852495-86-3
• MW: 575.7
• Purity: 99.26% (May vary between batches)
• Formula: C₃₅H₃₇N₅O₃
• SMILES: Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
• Target: Guanylate cyclase,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.47 mM);DMSO:60 mg/mL (104.22 mM)

Bioactivity

• Target IC50:
  GC:0.5 nM(EC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

topical, sGC, pressure, inhibit, intraocular, MGV 354, MGV354, MGV-354, ocular, Inhibitor, Guanylate Cyclase, activator, (Rac) MGV354, (Rac)MGV354, (Rac)-MGV354, (Rac)-MGV-354, drop

Compound Identifiers

PubChem CID

118627945