rac-CCT-250863 HCl

SKU: orb1745239

Description

rac-CCT-250863 HCl is a selective, reversible NEK2 inhibitor that induces cell cycle arrest and demonstrates anti-proliferative activity in cancer cell studies. Its apoptotic effects are enhanced in combination with Pomalidomide, supporting its investigation in combined anticancer therapy research both in vitro and in vivo.

Research Area

Cell Biology, Signal Transduction

Key Properties

• MW: 527
• Purity: 98.21% (May vary between batches)
• Formula: C₂₄H₂₆ClF₃N₄O₂S
• SMILES: NC1=C(C=C(C=N1)C2=CC(CN(C)C)=CS2)C3=CC(OC(/C=C\C(F)(F)F)C)=C(C(N)=O)C=C3.Cl
• Target: Apoptosis
• Solubility: DMSO:22.5 mg/mL (42.69 mM)

Bioactivity

• Target IC50:
  NEK2:0.073 µM|AMOL:7.1 μΜ|H929 multiple myeloma cells:8.0 μΜ|K12PE:8.7 μΜ

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, rac-CCT-250863 HCl(1364269-06-6 Free base), rac-CCT-250863 HCl

Compound Identifiers

PubChem CID

169553391