rac-BHFF

SKU: orb1223375

Description

Rac-BHFF is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). It exhibits anxiolytic activity in vivo and is orally active.

Key Properties

• CAS Number: 123557-91-5
• MW: 330.34
• Purity: >98% (HPLC)
• Formula: C₁₇H₂₁F₃O₃
• SMILES: CC(C)(C)c1cc(c2c(c1)C(C(=O)O2)(C(F)(F)F)O)C(C)(C)C
• Target: PERK
• Solubility: In Vitro: DMSO : 100 mg/mL (302.72 mM)

Bioactivity

• In Vivo:
  rac-BHFF has anxiolytic-like properties in stress-induced hyperthermia (SIH) in mice. rac-BHFF (3, 10, 30 and 100 mg/kg, p.o.) reverses SIH and high significance was reached for 100 mg kg 1 (P<0.001). Animal model: Male NMRI mice (20-25 g). Dosage: 3, 10, 30 or 100 mg/kg. Administration: p.o. Result: Significantly increased the LRR effects of a subthreshold dose of baclofen at doses of 3 mg/kg and above.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PERK