(Rac)-BDA-366

SKU: orb3133190

Description

(Rac)-BDA-366 (example 2) is the racemate of BDA-366, a potent Bcl-2 antagonist with a Ki of 3.3 nM. It shows high affinity and selectivity for the Bcl-2-BH4 domain. BDA-366 induces a conformational change in Bcl-2, neutralizing its anti-apoptotic function and converting Bcl-2 from a survival molecule into a cell death inducer. Additionally, BDA-366 can inhibit the growth of lung cancer cells.

Research Area

Signal Transduction

Key Properties

• CAS Number: 142645-19-0
• MW: 423.50
• Formula: C₂₄H₂₉N₃O₄
• SMILES: O=C1C=2C=CC=CC2C(=O)C=3C(=CC=C(NCC(O)CN(CC)CC)C13)NCC4OC4
• Target: Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Bcl-2 Family