(Rac)-Antineoplaston A10

SKU: orb1301840

Description

Antineoplaston A10 is a naturally occurring small molecule initially identified in the human body, recognized for its cell growth-inhibiting properties. It has been investigated in vitro and in vivo within oncology research for its potential antiproliferative effects against various cancer cell lines.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 77658-84-5
• MW: 246.26
• Purity: 98.47% (May vary between batches)
• Formula: C₁₃H₁₄N₂O₃
• SMILES: O=C(Cc1ccccc1)NC1CCC(=O)NC1=O
• Target: Apoptosis,Ras
• Solubility: DMSO:27.5 mg/mL (111.67 mM)

Bioactivity

• In Vitro:
  Antineoplaston A10 (2, 4, 8 mg/ml) inhibited cell proliferation time and dose-dependently in all 6 HCC cell lines. A concentration of 8 mg/ml of Antineoplaston A10 was required to inhibit cell proliferation in KIM-1, KYN-3, HAK-1A, and HAK-1B cells . The HepG2 cells, when incubated with 10 μg/ml of antineoplaston A10, had a cell growth inhibition rate of less than 10% for up to 120 h, while cells incubated with 200 μg/ml of antineoplaston A10 had an inhibition rate of 34.9% at 120 h .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, (Rac) Antineoplaston A10, (Rac)Antineoplaston A10, (Rac)-Antineoplaston A10, (Rac)-Antineoplaston A-10, Antineoplaston A10, Apoptosis, Ras

Compound Identifiers

PubChem CID

157096