(Rac)-Acolbifene

SKU: orb1708725

Description

(Rac)-Acolbifene (EM-343) is the racemic mixture of the selective estrogen receptor modulator (SERM) Acolbifene. This compound, which features a piperidine ring, acts as an estrogen receptor antagonist with a relative binding affinity (RBA) of 380, demonstrating both anti-estrogenic and estrogenic activities in research models. It is utilized in preclinical studies to investigate hormone-responsive conditions such as breast cancer.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 151533-34-5
• MW: 457.56
• Purity: 99.70% (May vary between batches)
• Formula: C₂₉H₃₁NO₄
• SMILES: CC1=C(C(Oc2cc(O)ccc12)c1ccc(OCCN2CCCCC2)cc1)c1ccc(O)cc1
• Target: Estrogen Receptor/ERR
• Solubility: DMSO:90 mg/mL (196.7 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.21 mM)

Bioactivity

• In Vivo:
  In ovariectomized mice, (Rac)-Acolbifene (7.5 nM, 75 nM; oral) shows shows 63% and 84% antiuterotrophic inhibitions, respectively.
• In Vitro:
  In T-47D cells, (Rac)-Acolbifene (0.110 nM) inhibits cell growth with an IC50 value of 0.110 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Acolbifene, (Rac)-EM-652, EstrogenReceptor, estrogen receptor, Estrogen Receptor, EM343, EM-343, EM 652, EM652, EM-652, EM 343, ERR

Compound Identifiers

PubChem CID

9804157