Rabies virus (strain CVS-11) Nucleoprotein, His Tag

SKU: orb3158039

Description

Rabies virus (RABV), scientific name Rabies lyssavirus, is a deadly neurotropic virus that causes rabies in humans and animals. Rabies virus has an extremely wide host range and its transmission most often occur through the saliva of animals. Without intervention prior to disease progression, rabies has the highest case fatality of any infectious disease. RABV contains a single-stranded negative-sense RNA genome that encodes five structural proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G), and RNA-dependent RNA polymerase (L). RABV N protein is 450 amino acids long and serves the critical function of tightly packaging the RNA genome into an RNase-resistant core. Encapsidation of the genomic RNA by newly synthesized N is believed to switch viral RNA from transcription to replication. Furthermore, N is a major antigen for RABV to stimulate Th cells and antibody production.

Research Area

Infectious Disease & Virology

Images & Validation

• Application Notes:
  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 52.7 kDa. The protein migrates as 55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

• Expression System: InsectCells
• Target: Nucleoprotein
• Reactivity: Rabies virus
• Tag: C-10×His
• Expression Region: Met 1 - Ser 450
• Endotoxins: 1.0 EU per μg
• Conjugation: Unconjugated
• MW: 52.7 kDa
• Purity: 90%

Storage & Handling

• Storage: -70°C
• Form/Appearance: Liquid
• Buffer/Preservatives: 50 mM Tris, 500 mM NaCl, pH 7.5
• Expiration Date: 6 months from date of receipt.
• Dry Ice Shipping: Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Nucleoprotein

UniProt

Q8JXF6

RefSeq:Q8JXF6