Rabeximod

SKU: orb1695532

Description

Rabeximod is a small molecule immunomodulator that acts via TLR2 and TLR4 stimulation to suppress inflammatory cell activation. It demonstrates efficacy in reducing arthritis severity in rodent models and has shown potential in modulating neuroinflammation and antigen presentation following traumatic brain injury in mice.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 872178-65-9
• MW: 409.91
• Purity: 99.99% (May vary between batches)
• Formula: C₂₂H₂₄ClN₅O
• SMILES: C(C(NCCN(C)C)=O)N1C=2C(C=3C1=CC=C(Cl)C3)=NC=4C(N2)=CC(C)=C(C)C4
• Target: TLR
• Solubility: DMSO:Slightly soluble

Bioactivity

• In Vivo:
  Rabeximod efficiently prevented arthritis during the time window when TLR2 or TLR4 ligands activate inflammatory macrophages. The effect operated downstream of TLR activation as Rabeximod was highly therapeutic in CAIA enhanced through TLR2 stimuli in TLR4 deficient mice. In addition, it was found that the arthritis ameliorating effect of Rabeximod was time dependent, since inhibition of tumour necrosis factor α production from macrophages in vitro was more pronounced if administered close to stimulation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rabeximod, TLR2, TLR4, ROB 803, ROB803, ROB-803

Compound Identifiers

PubChem CID

56841552