RA375

SKU: orb1303892

Description

RA375 is a potent small molecule inhibitor of the proteasome regulatory subunit RPN13, exhibiting enhanced pro-apoptotic activity through UPR activation and ROS induction. Its superior cytotoxicity, attributed to a nitroaryl group and chloroacetamide warhead, makes it a valuable chemical probe for studying proteasome biology and cancer cell death mechanisms in vitro.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 2649154-57-2
• MW: 588.99
• Purity: 99.56% (May vary between batches)
• Formula: C₃₀H₂₅ClN₄O₇
• SMILES: O=C(CCl)N[C@H](C(N1C/C(C(/C(C1)=C/C2=CC=C([N+]([O-])=O)C=C2)=O)=C\C3=CC=C([N+]([O-])=O)C=C3)=O)CC4=CC=CC=C4
• Target: Apoptosis,Proteasome,Reactive Oxygen Species,ROS
• Solubility: DMSO:125 mg/mL (212.23 mM)

Bioactivity

• In Vivo:
  RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RA 375, RA375, RA-375, 26S proteasome

Compound Identifiers

PubChem CID

146681207