R8-T198wt

SKU: orb1679225

Description

This cell-permeable peptide inhibitor, derived from p27Kip1, selectively blocks Pim-1 kinase activity. It inhibits phosphorylation of targets like Bad, inducing G1 arrest and apoptosis in DU145 prostate cancer cells in vitro and in vivo, while sparing normal prostate epithelial cells. This makes it a valuable research tool for studying Pim-1-driven oncogenesis and therapeutic strategies.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• Target: Pim
• CAS Number: 2305815-72-7
• MW: 2820.33
• Formula: C₁₁₁H₂₁₁N₅₉O₂₆S
• SMILES: C([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(CNC(CN)=O)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CS)=O)CCCCN)=O)CCCCN)(=O)N1[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(C)C)=O)=O)CCC1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

90488955