(R)-Zanubrutinib

SKU: orb1708132

Description

(R)-Zanubrutinib is a potent and selective small molecule inhibitor targeting Bruton's tyrosine kinase (BTK). It is utilized in biochemical and cellular research to investigate B-cell receptor signaling and has demonstrated efficacy in preclinical models of B-cell malignancies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1691249-44-1
• MW: 471.55
• Purity: 99.55% (May vary between batches)
• Formula: C₂₇H₂₉N₅O₃
• SMILES: NC(=O)c1c2NCC[C@H](C3CCN(CC3)C(=O)C=C)n2nc1-c1ccc(Oc2ccccc2)cc1
• Target: BTK
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (5.3 mM);DMSO:57.8 mg/mL (122.57 mM);Ethanol:< 1?mg/mL?(insoluble?or?slightly?soluble)

Bioactivity

• Target IC50:
  BTK:0.011 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Zanubrutinib, BGB3111, BGB-3111, BGB 3111, BTK, (R)-BGB-3111

Compound Identifiers

PubChem CID

137071299