(R)-Thalidomide

SKU: orb1990517

Description

(R)-Thalidomide is a COX-1/2 inhibitor that triggers programmed cell death in various cancer cell lines, including MCF-7 and KB cells. Its research applications include studying anti-inflammatory and anti-cancer mechanisms in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2614-06-4
• MW: 258.23
• Purity: 99.87% (May vary between batches)
• Formula: C₁₃H₁₀N₂O₄
• SMILES: O=C1N(C(=O)C=2C1=CC=CC2)[C@H]3C(=O)NC(=O)CC3
• Target: Autophagy,Apoptosis,Ligands for E3 Ligase,Molecular Glues,COX
• Solubility: DMSO:10 mg/mL (38.73 mM)

Bioactivity

• In Vivo:
  Methods: Adult female F344 rats were implanted with 9L gliosarcoma tumors intracranially, subcutaneously (flank), or both. The efficacy of oral thalidomide alone and in combination with intraperitoneal BCNU or cisplatin was evaluated after several weeks of treatment. S- and (R)-Thalidomide were measured by chiral HPLC in presumed pseudo-steady-state serum, tumor, and other tissues collected after treatment. Results: Serum and tissue concentrations of (R)-Thalidomide were 40-50% higher than those of (S)-Thalidomide.
  Read more...
• In Vitro:
  With the affinity of (R)-Thalidomide by the MIP present surface capture, that is more strongly than the other forms. In the case of (R)-Thalidomide, it is found to bind to the selective sites of the MIP more strongly than the other which reflects their different biological entities. The (S)-Thalidomide imprints MIP nanoparticles exerted a greater cytotoxic effect on the caco-2 cells than the (R)-Thalidomide imprinted MIPs.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(R)-(+)-Thalidomide, (R)Thalidomide, (R) Thalidomide, Thalidomide

Compound Identifiers

PubChem CID

75792