R-IMPP

SKU: orb1303221

Description

R-IMPP is a small molecule inhibitor that suppresses PCSK9 protein synthesis, thereby upregulating hepatic LDL receptor levels and enhancing LDL cholesterol uptake in hepatoma cell models. This mechanism, which does not affect transferrin secretion, makes it a valuable research tool for studying lipid metabolism and potential therapeutic strategies for hypercholesterolemia in both in vitro and in vivo contexts.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 2133832-83-2
• MW: 389.49
• Purity: 99.85%
• Formula: C₂₄H₂₇N₃O₂
• SMILES: COc1ccc(CCC(=O)N([C@@H]2CCCNC2)c2nccc3ccccc23)cc1
• Target: Serine/threonin kinase,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.13 mM);DMSO:70 mg/mL (179.72 mM)

Bioactivity

• Target IC50:
  PCSK9:4.8 μM IC50

Storage & Handling

• Storage: store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, PCSK9, Ser/Thr Protease, Serine kinase, Serine endopeptidases, PF 00932239, Serine proteases, threonin kinase, Serinekinase, Threonine proteases, threoninkinase, PF-00932239, PF00932239, R IMPP, RIMPP, R-IMPP

Compound Identifiers

PubChem CID

122198706