(R)-(-)-Ibuprofen

SKU: orb1706427

Description

(R)-(-)-Ibuprofen is the R-enantiomer of ibuprofen, functioning as an inhibitor of NF-κB activation. This compound exhibits anti-inflammatory and antinociceptive properties, making it a valuable tool for research in pharmacology and inflammation biology, applicable in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 51146-57-7
• MW: 206.28
• Purity: 99.86% (May vary between batches)
• Formula: C₁₃H₁₈O₂
• SMILES: CC(C)Cc1ccc(cc1)[C@@H](C)C(O)=O
• Target: NF-κB
• Solubility: DMSO:45 mg/mL (218.15 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.7 mM)

Bioactivity

• In Vitro:
  (R)-(-)-Ibuprofen participates in lipid metabolism pathways and integrates into triglycerides alongside endogenous fatty acids. It inhibits NF-κB luciferase activity (IC50: 121.8 μM), less potently than S(+)-ibuprofen (IC50: 61.7 μM). At 1 μM, it significantly reduces NF-κB activation and completely prevents its induction at 10 μM. Additionally, (R)-(-)-Ibuprofen (10 mM) does not affect HSF .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(R)-Ibuprofen|Ibuprofen|levibuprofen|NF-κB|NFκB|NF-kB|NFkB

Compound Identifiers

PubChem CID

114864