R-HP210

SKU: orb1687788

Description

R-HP210 is a small molecule inhibitor of NF-κB-mediated transcription, effectively suppressing LPS-induced expression of pro-inflammatory genes like IL-1β, IL-6, and COX-2 with an IC50 of 3.80 µM. It functions as a selective glucocorticoid receptor modulator, demonstrating anti-inflammatory activity in cellular models without inducing transactivation. This profile makes it a useful research tool for studying inflammatory pathways in vitro.

Research Area

Signal Transduction

Key Properties

• MW: 421.53
• Purity: 99.35% (May vary between batches)
• Formula: C₂₂H₁₉N₃O₂S₂
• SMILES: O=C(C1=CC=C(CN2C(NC(C=CS3)=C3C2=O)=S)C=C1)N[C@H](C)C4=CC=CC=C4
• Target: NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NF-κB