(R)-baclofen

SKU: orb1300840

Description

STX209, the (R)-enantiomer of baclofen, is a GABA derivative used in research to study spasticity mechanisms. It serves as a selective GABAB receptor agonist for in vitro binding assays and in vivo models of neurological disorders, including spinal cord injury and multiple sclerosis.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 69308-37-8
• MW: 213.66
• Purity: 97.20%
• Formula: C₁₀H₁₂ClNO₂
• SMILES: NC[C@H](CC(O)=O)c1ccc(Cl)cc1
• Target: GABA Receptor
• Solubility: DMSO:Insoluble;H2O:10 mM

Bioactivity

• In Vitro:
  Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-( )-enantiomer is about 100 times more active than the S-(+)-enantiomer.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Gamma-aminobutyric acid Receptor, GABA Receptor, GABAReceptor, GABAR, Arbaclofen, baclofen, (R)baclofen, (R)-Baclofen, (R) baclofen, STX209, STX-209, STX 209, γ-Aminobutyric acid Receptor

Compound Identifiers

PubChem CID

44602