R-130823

SKU: orb1740029

Description

R-130823 is a potent and selective p38α MAPK inhibitor (IC50=22 nM) that suppresses pro-inflammatory cytokine release in vitro. It demonstrates significant in vivo efficacy by reducing established paw swelling and hyperalgesia in a rat adjuvant-induced arthritis model.

Key Properties

• CAS Number: 321344-32-5
• MW: 423.52
• Formula: C₂₈H₂₆FN₃
• SMILES: C(CC1=CC=CC=C1)N2CCC(C=3C(=C(NC3)C4=CC=C(F)C=C4)C=5C=CN=CC5)=CC2
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

9910199