Quisinostat HCl

SKU: orb2647233

Description

Quisinostat, also known as JNJ-26481585, is an orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation.

Key Properties

• CAS Number: 875320-31-3
• MW: 430.931082963943
• Purity: >98%
• Formula: C₂₁H₂₇CLN₆O₂
• SMILES: Cl.O=C(C1C=NC(N2CCC(CNCC3C4C(=CC=CC=4)N(C)C=3)CC2)=NC=1)NO

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only