Quinolinic acid

SKU: orb1221680

Description

Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.

Key Properties

• CAS Number: 89-00-9
• MW: 173.17
• Purity: >98% (HPLC)
• Formula: C₁₀H₇NO₂
• SMILES: OC(=O)c1cccnc1C(O)=O
• Target: NMDA receptor
• Solubility: DMSO : 33.33 mg/mL 199.44 mM

Bioactivity

• In Vitro:
  Quinolinic acid (0-50 mM; 24 hours) decreases the percentage of survival cells ranging from 100±0.01% at 5 mM to 45.23±0.01% at 50 mM in N18D3 cells. Cell Viability Assay Cell line: N18D3 cells, hybrid neuronal cell line obtained by fusion of dorsal root ganglions isolated from 4-week-old Balb/C mouse with the mouse neuroblastoma N18TG2 cells. Concentration: 0, 10, 20, 30, 40, 50 mM. Incubation time: 24 hours. Result: There was a corresponding decrease in the percentage of survival cells ranging from 100±0.01% at 5 mM to 45.23±0.01% at 50 mM.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NMDA receptor