Quinine hydrochloride dihydrate

SKU: orb1300601

Description

Quinine hydrochloride dihydrate

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 6119-47-7
• MW: 396.91
• Purity: 99.04%
• Formula: C₂₀H₂₄N₂O₂·HCl·2H₂O
• SMILES: O.O.Cl.COc1ccc2nccc([C@@H](O)C3C[C@H]4CCN3C[C@@H]4C=C)c2c1
• Target: Potassium Channel,Parasite,Anti-infection
• Solubility: DMSO:50 mg/mL (125.97 mM);H2O:43 mg/mL (108.34 mM);Ethanol:79 mg/mL (199.04 mM)

Bioactivity

• In Vitro:
  Quinine blocks Cx36 and Cx50 junctional currents in a reversible and concentration-dependent manner with half maximal blocking concentrations of 32 mM and 73 mM, respectively. Quinine induces slow transitions between open and fully closed states that decreased open probability of the channel. Quinine thus offers a potentially useful method to block certain types of gap junction channels, including those between neurons that are formed by Cx36. Quinine, a K+ channel blocker, prevents formation of tumor necrosis factor (TNF) as well as the subsequent hepatic DNA fragmentation and liver enzyme leakage. Quinine elicits Fos-like immunoreactivity (FLI) concentrated in the medial third of the nucleus; acid elicited more broadly distributed FLI concentrated farther laterally. Quinine has a relatively weak effect on doxorubicin accumulation but was able to completely restore doxorubicin sensitivity in the resistant cells. Quinine also modifies the intracellular tolerance to doxorubicin, which suggests that it is able to modify drug distribution within the cells. Quinine primarily blocks the whole cell potassium currents (IK) in a voltage-dependent manner. Quinine also reduces the size of sodium currents (INa) in a use-dependent manner, while leaving calcium currents (ICa) relatively unaffected.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Potassium channel, Potassium Channel, PotassiumChannel, Quinine, Quinine HCl, Quinine HCl Dihydrate, Quinine Hydrochloride, Quinine hydrochloride dihydrate, Quinine hydrochloride Dihydrate, anti-malarial, cinchonaine, Inhibitor, Parasite, KcsA, inhibit

Compound Identifiers

PubChem CID

155859213