Quinidine

SKU: orb1299368

Description

Quinidine is a stereoisomer of quinine and functions as a class Ia antiarrhythmic agent. It is utilized in research on cardiac arrhythmias and malaria, serving as a pharmacological tool for both in vitro electrophysiology studies and in vivo animal models of disease.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 56-54-2
• MW: 324.42
• Purity: 99.99% (May vary between batches)
• Formula: C₂₀H₂₄N₂O₂
• SMILES: [H][C@@]12CCN(C[C@@H]1C=C)[C@H](C2)[C@@H](O)c1ccnc2ccc(OC)cc12
• Target: Potassium Channel,Parasite,Apoptosis,Cytochromes P450
• Solubility: DMSO:50 mg/mL (154.12 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.16 mM)

Bioactivity

• In Vitro:
  Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner.It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Quinidine, Potassium Channel, Apoptosis, CYPs, Cytochrome P450, KcsA, inhibit, Inhibitor, Parasite, MES-SA, MESSA/DX5, oral activity, malaria

Compound Identifiers

PubChem CID

441074