Quinacrine Dihydrochloride Dihydrate

SKU: orb1704794

Description

Quinacrine hydrochloride hydrate

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 6151-30-0
• MW: 508.91
• Formula: C₂₃H₃₆Cl₃N₃O₃
• SMILES: ClC(C=CC1=C2NC(CCCN(CC)CC)C)=CC1=NC3=C2C=C(OC)C=C3.Cl.O.Cl.O
• Target: Wnt/beta-catenin,Topoisomerase,Antibiotic,Parasite,p53,Apoptosis,Autophagy

Bioactivity

• In Vivo:
  Quinacrine Dihydrochloride Dihydrate (100 mg/kg, administered via gavage, three times per week for two consecutive weeks) reduced the proportion of homo sapiens-derived tumor cells in female severe combined immunodeficiency (SCID) mice with acute myeloid leukemia (AML)-PS models to 2.2%, and extended the median survival time of the mice to 46 days .
• In Vitro:
  Quinacrine Dihydrochloride Dihydrate inhibits the growth of SGC-7901 cells at concentrations of 5-20 μM with an exposure time of 24 hours . Quinacrine Dihydrochloride Dihydrate induces apoptosis in SGC-7901 cells at concentrations of 7.5 and 15 μM with an exposure time of 24 hours; this apoptotic process is associated with the mitochondrial-dependent signaling pathway and involves upregulation of p53 protein and activation of the caspase-3 protein pathway . Treatment of cells with Quinacrine Dihydrochloride Dihydrate at a concentration of 15 μM for 24 hours significantly increases the levels of pro-apoptotic proteins (including cytochrome c, Bax protein, and p53 protein) while reducing the level of the anti-apoptotic protein Bcl-2, thereby shifting the Bax/Bcl-2 ratio in a direction favorable to apoptosis .

Storage & Handling

• Storage: keep away from direct sunlight | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Quinacrine hydrochloride hydrate, Quinacrine Dihydrochloride, Quinacrine Dihydrochloride Dihydrate, SN-390 hydrochloride hydrate, Mepacrine Dihydrochloride, Mepacrine Dihydrochloride Dihydrate, Mepacrine hydrochloride hydrate

Compound Identifiers

PubChem CID

23581813