Quercetin Dihydrate

SKU: orb1300602

Description

Quercetin Dihydrate

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 6151-25-3
• MW: 338.27
• Purity: 97.03%
• Formula: C₁₅H₁₀O₇·2H₂O
• SMILES: O.O.Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
• Target: Apoptosis,PI3K
• Solubility: DMSO:45 mg/mL (133.03 mM);Ethanol:15 mg/mL (44.34 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.91 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  PI3Kγ:2.4 μM (IC50)|PI3Kβ:5.4 μM (IC50)|PI3Kδ:3.0 μM (IC50)
• In Vivo:
  LD50: Mice 159 mg/kg (i.g.)
• In Vitro:
  Quercetin, a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. The pharmacological activities of quercetin that modulate antioxidation/oxidation/kinase-signaling pathways might be differentially elicited in neurons compared with malignant cells, ultimately promoting cell survival or death in a cell type- and metabolism-specific manner. Whereas the broad antioxidation and anti-inflammatory activities of quercetin are important for neuronal survival, the oxidative, kinase- and cell cycle-inhibitory, apoptosis-inducing effects of quercetin are essential for its anticancer effects.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sophoretin, Phosphoinositide 3-kinase, PI3K, Quercetin Dihydrate, Quercetin, Apoptosis, Inhibitor, inhibit

Compound Identifiers

PubChem CID

5284452