Quercetagetin

SKU: orb1299208

Description

Quercetagetin (6-Hydroxyquercetin) is a flavonoid primarily isolated from Citrus unshiu. It acts as a cell-permeable, selective Pim-1 kinase inhibitor with an IC50 of 0.34 µM, making it a useful research tool for studying kinase signaling in cancer and other cellular models, both in vitro and in vivo.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 90-18-6
• MW: 318.24
• Purity: 99.91% (May vary between batches)
• Formula: C₁₅H₁₀O₈
• SMILES: Oc1ccc(cc1O)-c1oc2cc(O)c(O)c(O)c2c(=O)c1O
• Target: Pim
• Solubility: DMSO:250 mg/mL (785.57 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.57 mM)

Bioactivity

• Target IC50:
  Pim1:0.34 μM|RSK2:2.82 μM|PKA:21.2 μM|Pim2:3.5 μM
• In Vivo:
  Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively .
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• In Vitro:
  Quercetagetin inhibits PIM2, PKA, and RSK2 (IC50s: 3.45, 21.2, and 2.82 μM). Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM .
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• Cell Research:
  Cell Line: RWPE2 prostate cancer cells. Concentration: 0.1, 1, 10, and 100 μM. Incubation Time: 72 hours
• Animal Research:
  Animal Model: SKH-1 hairless mice model. Dosage: 4 or 20 nmol. Administration: Topical application; 28 weeks

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

6-Hydroxyquercetin, inhibit, Inhibitor, Pim1, Pim kinases, Pim, Quercetagetin

Compound Identifiers

PubChem CID

5281680