Quarfloxin

SKU: orb1307820

Description

Quarfloxin (CX-3543) is a fluoroquinolone-derived anticancer agent that potently inhibits neuroblastoma cell growth by disrupting the nucleolin-G-quadruplex DNA complex in ribosomal DNA. Its application extends to cancer research, where it has been investigated in both in vitro and in vivo models for its mechanism of action and therapeutic potential.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 865311-47-3
• MW: 604.67
• Purity: 99.77% (May vary between batches)
• Formula: C₃₅H₃₃FN₆O₃
• SMILES: CN1CCC[C@H]1CCNC(=O)c1cn2c3cc4ccccc4cc3oc3c(N4CCC(C4)c4cnccn4)c(F)cc(c23)c1=O
• Target: DNA/RNA Synthesis
• Solubility: DMSO:55 mg/mL (90.96 mM);H2O:1 mg/mL (1.65 mM)

Bioactivity

• In Vitro:
  Quarfloxin effectively inhibits the growth of neuroblastoma cells in vitro. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CX3543, CX-3543, CX 3543, DNASynthesis, DNA Synthesis, DNA/RNA Synthesis, inhibit, Inhibitor, Quarfloxin, RNA polymerase I, RNA pol I, RNA Synthesis, RNASynthesis

Compound Identifiers

PubChem CID

91263893