QS 11

SKU: orb1222977

Description

QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.(In Vitro):QS11 binds and inhibits the GTPase activating protein of ARFGAP1, suggesting that QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking.QS11 (2.5 μM) activates the Super(8X)TOPFlash reporter 200-fold in the presence of Wnt-3a conditioned medium, whereas Wnt-3a treatment alone increases reporter activity 40-fold.QS11 shows potent activity (EC50=0.5 μM) with little cytotoxicity toward HEK293 and human primary fibroblast cells.QS11 effectively reduces in vitro migration of metastatic human breast cancer cells.

Key Properties

• CAS Number: 944328-88-5
• MW: 567.7
• Purity: >98% (HPLC)
• Formula: C₃₆H₃₃N₅O₂
• SMILES: OC[C@H](Cc1ccccc1)Nc1c2c(n(Cc3ccc(c4ccccc4)cc3)cn2)nc(Oc2ccc3CCCc3c2)n1
• Target: CDK
• Solubility: DMSO : ≥ 100 mg/mL 176.16 mM; H2O : < 0.1 mg/mL

Bioactivity

• In Vitro:
  QS11 binds and inhibits the GTPase activating protein of ARFGAP1, suggesting that QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 (2.5 μM) activates the Super(8X)TOPFlash reporter 200-fold in the presence of Wnt-3a conditioned medium, whereas Wnt-3a treatment alone increases reporter activity 40-fold. QS11 shows potent activity (EC50 = 0.5 μM) with little cytotoxicity toward HEK293 and human primary fibroblast cells. QS11 effectively reduces in vitro migration of metastatic human breast cancer cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

QS11 | QS-11 | QS 11

Quick Database Links

Gene Symbol

CDK