QNZ46

SKU: orb1223374

Description

QNZ46 is a NMDA receptor antagonist. QNZ46 inhibits NMDA receptor function in a noncompetitive and voltage-independent manner by an unconventional mechanism that requires binding of glutamate to the GluN2 subunit, but not glycine binding to the GluN1 subunit. QNZ46 could provide an opportunity for the development of pharmacological tools and therapeutic agents that target NMDA receptors at a new site and modulate function by a novel mechanism. NMDA receptors are ionotropic glutamate receptors that mediate excitatory synaptic transmission and have been implicated in several neurological diseases.

Key Properties

• CAS Number: 1237744-13-6
• MW: 443.41
• Purity: >98% (HPLC)
• Formula: C₂₄H₁₇N₃O₆
• SMILES: COc1cc2c(cc1)nc(n(c2=O)c1ccc(cc1)C(=O)O)/C=C/c1cc(ccc1)[N+](=O)[O-]
• Target: MEK
• Solubility: DMSO : ≥ 4.5 mg/mL10.15 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

QNZ46 | QNZ-46 | QNZ 46

Quick Database Links

Gene Symbol

MEK