QL47

SKU: orb1706747

Description

QL47 is a host-targeted small molecule with dual antiviral and anticancer research applications. It functions as a viral translation inhibitor against dengue and other RNA viruses and as a covalent BTK inhibitor, supporting its investigation in virology and lymphoma research models.

Research Area

Cardiovascular Research, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 1469988-75-7
• MW: 447.49
• Purity: 98.11% (May vary between batches)
• Formula: C₂₇H₂₁N₅O₂
• SMILES: Cn1cc(cn1)-c1ccc2ncc3ccc(=O)n(-c4ccc5CCN(C(=O)C=C)c5c4)c3c2c1
• Target: Virus Protease,BTK,Anti-infection
• Solubility: DMSO:1 mg/mL (2.23 mM)

Bioactivity

• Target IC50:
  PLCγ2/Tyr 759:318 nM|Tyr223:475 nM (EC50)
• In Vitro:
  QL47 inhibits protein neosynthesis initiated by both canonical cap-driven and noncanonical initiation strategies, likely by targeting an early step in translation elongation. With EC50 values of 475 nM and 318 nM, QL47 inhibits BTK autophosphorylation on Tyr223 and phosphorylation of the downstream effector PLCγ2 (Tyr759) in cells, respectively. In Ramos cells, QL47 induces G1 cell cycle arrest and significant BTK protein degradation. Additionally, QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

QL 47, QL47, QL-47, VirusProtease, Virus Protease, BTK, Dengue Fever virus

Compound Identifiers

PubChem CID

71748056