QL-X-138 HCl

SKU: orb1962219

Description

QL-X-138 HCl is a novel covalent BTK and non-covalent MNK dual-kinase inhibitor with demonstrated anti-proliferative activity in acute myeloid leukemia cells in vitro and anti-dengue virus 2 activity, applicable for research in hematological malignancies like lymphoma and leukemia.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• MW: 457.91
• Purity: 98.89% (May vary between batches)
• Formula: C₂₅H₂₀ClN₅O₂
• SMILES: O=C(NC1=CC(N2C(C=CC3=CN=C4C=CC(C5=CNN=C5)=CC4=C32)=O)=CC=C1C)C=C.Cl[H]
• Target: BTK,MNK

Bioactivity

• Target IC50:
  PLCγ2 Y1217:57 nM (EC50)|BTK Y223:11 nM (EC50)
• In Vitro:
  In Ramos, OCI-AML3, U2932, TMD8, and U937 cells, QL-X-138 HCl(3-10000 nM; 4 hours) significantly inhibited the auto-phosphorylation of BTK Y223 (EC50=11 nM).QL-X-138 HCl strongly blocked the phosphorylation of the BTK downstream target PLCγ2 Y1217 (EC50=57 nM) and suppressed the phosphorylation of the MNK downstream target eIF4E S209 at a concentration of 1 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BTK, MNK, QL-X-138 HCl(1469988-63-3 Free base)

Compound Identifiers

PubChem CID

171360546