Qingyangshengenin B

SKU: orb1297629

Description

Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside with neuroprotective properties, notably reducing Aβ peptide expression and deposition. Research demonstrates its in vivo efficacy in extending lifespan and enhancing stress resistance in C. elegans AD models, alongside exhibiting antiepileptic activity in zebrafish seizure assays.

Research Area

Neuroscience

Key Properties

• CAS Number: 106758-54-7
• MW: 923.13
• Purity: 99.51% (May vary between batches)
• Formula: C₄₉H₇₈O₁₆
• SMILES: O[C@]12[C@](C)([C@H](OC(/C=C(/C(C)C)\C)=O)C[C@]3([C@@]1(O)CC=C4[C@]3(C)CC[C@H](O[C@H]5C[C@H](OC)[C@H](O[C@H]6C[C@H](OC)[C@H](O[C@H]7C[C@@H](OC)[C@H](O)[C@@H](C)O7)[C@@H](C)O6)[C@@H](C)O5)C4)[H])[C@@](C(C)=O)(O)CC2
• Target: Beta Amyloid
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.08 mM);DMSO:5 mg/mL (5.42 mM)

Bioactivity

• In Vitro:
  Otophylloside B (Ot B) could modestly extend the lifespan of C. elegans, delay the age-related decline of body movement and improve the stress resistance. Further investigating the molecular mechanism of lifespan extension effect revealed that Ot B could activate the FOXO transcription factor DAF-16. Ot B could not further extend the lifespan of long-lived mutant of insulin/IGF-1-like receptor (daf-2). In addition, Ot B also requires SIR-2.1 and CLK-1 which is an enzyme in ubiquinone synthesis, for lifespan extension.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Otophylloside B, inhibit, Inhibitor, bAmyloid, Amyloid-β, b Amyloid, Abeta, BetaAmyloid, Beta Amyloid, Qingyangshengenin B, β-amyloid peptide, βAmyloid, β Amyloid

Compound Identifiers

PubChem CID

10079485