Q203

SKU: orb1301821

Description

Q203

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 1334719-95-7
• MW: 557.01
• Purity: 99.47%
• Formula: C₂₉H₂₈ClF₃N₄O₂
• SMILES: CCc1nc2ccc(Cl)cn2c1C(=O)NCc1ccc(cc1)N1CCC(CC1)c1ccc(OC(F)(F)F)cc1
• Target: Antibacterial,Antibiotic
• Solubility: H2O:Insoluble;DMSO:11 mg/mL (19.75 mM)

Bioactivity

• Target IC50:
  Mycobacterium tuberculosis H37Rv:2.7 nM ( IC50
• In Vivo:
  Q203 had a bioavailability of 90% and a terminal half-life of 23.4 h the volume of distribution was moderate (5.27 l per kg body weight), an the systemic clearance was low (4.03 mL/min/kg). It promoted a reduction in bacterial load of more than 90% at a dose of 10 mg per kg body weight, an effect comparable to that of bedaquiline or isoniazid.
• In Vitro:
  Q203 was active agains the reference strain M. tuberculosis H37Rv at a minimum concentration required to inhibi the growth of 50% of organisms ( IC50 of 2.7 nM in culture broth medium and at an IC50 of 0.28 nM inside macrophages. Verapamil increase the potency of Q203 against Mycobacterium tuberculosis both in vitro and ex vivo. Inhibition of cytochrome bd, a parallel branch o the mycobacterial respiratory chain, by aurachin D invoked bactericidal activity of Q203. Inhibition of respiratory chain activity by Q203 was incomplete, but could be enhanced by inactivation of cytochrome bd, either by genetic knock-out or by Inhibition with aurachin D.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Bacterial, Antibiotic, IAP 6, IAP6, IAP-6, Inhibitor, inhibit, Q 203, Q203, Q-203, tuberculosis, Telacebec

Compound Identifiers

PubChem CID

68234908