PZL-A

SKU: orb2946004

Description

PZL-A is a small molecule activator of mitochondrial DNA synthesis. It rescues the function of common pathogenic POLγ mutants, enhancing oxidative phosphorylation and mitochondrial biogenesis in patient-derived cells. This compound is a research tool for studying mtDNA depletion syndromes and potential therapeutic strategies.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 3068830-89-4
• MW: 368.82
• Purity: 99.88% (May vary between batches)
• Formula: C₁₉H₁₇ClN₄O₂
• SMILES: N(C(NC1=NN(C=C1)C2=CC=CC=C2)=O)[C@@H]3C=4C(OCC3)=C(Cl)C=CC4
• Target: Mitochondrial Metabolism,OXPHOS,DNA/RNA Synthesis

Bioactivity

• In Vitro:
  PZL-A (1 μM; 37 °C, 15–60 min) enhanced DNA polymerase activity of mutant POLγ complexes in primer extension assays using recombinant enzymes and M13 ssDNA. PZL-A improved processivity without affecting exonuclease function.PZL-A (≥10 nM; 4–7 d) promoted mtDNA recovery and improved mitochondrial function in POLG-mutant patient fibroblasts and neural stem cells after ethidium bromide–induced depletion.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1-[(4S)-8-Chlorochroman-4-yl)-3-(1-phenylpyrazol-3-yl)urea, PZLA

Compound Identifiers

PubChem CID

172916360