PZ15227

SKU: orb3218131

Description

PZ15227 is a PROTAC degrader targeting the Bcl-xl protein, selectively degrading Bcl-xl in senescent cells by binding to the CRBN E3 ubiquitin ligase. As a derivative of ABT-263, PZ15227 retains antitumor activity while significantly reducing platelet toxicity.

Key Properties

• Target: Bcl-2 Family,PROTACs
• Molecular Weight: 1484.13
• Purity: 99.76% (May vary between batches)
• CAS Number: 2143464-25-7
• Formula: C₇₁H₈₂ClF₃N₁₂O₁₂S₃
• SMILES: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCC4=CN(CCCC(=O)N5CCN(CC[C@@H](NC6=C(S(C(F)(F)F)(=O)=O)C=C(S(NC(=O)C7=CC=C(C=C7)N8CCN(CC9=C(CCC(C)(C)C9)C%10=CC=C(Cl)C=C%10)CC8)(=O)=O)C=C6)CSC%11=CC=CC=C%11)CC5)N=N4

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Bcl-2 Family,PROTACs