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PZ-1657 hydrochloride

SKU: orb3174616

Description

PZ-1657 hydrochloride (Compound 57) is a potent, selective, and orally active 5-HT7 receptor inverse agonist, with a Ki value of 5 nM. It inhibits constitutive cAMP production mediated by the Gs signaling pathway, with an EC50 value of 2.93 nM. PZ-1657 hydrochloride significantly reduces 5-HT7 receptor-mediated MMP-9 activity in the mouse hippocampus, showing effects comparable to SB-269970. It reverses cognitive deficits induced by phencyclidine in a rat novel object recognition test without affecting spontaneous activity. PZ-1657 hydrochloride is useful for researching affective disorders such as depression and bipolar disorder.

Research Area

Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

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PZ-1657 hydrochloride

Key Properties

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Target5-HT Receptor,MMP,Dopamine Receptor

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quick Database Links

Gene Symbol
5-HT Receptor,MMP,Dopamine Receptor

Protocol Information

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