Pyrvinium pamoate

SKU: orb1299911

Description

Pyrvinium pamoate is a classic anthelmintic agent for enterobiasis that has regained interest as a potential anticancer compound. It functions by inhibiting the Wnt/β-catenin signaling pathway, demonstrating activity in both in vitro cellular assays and in vivo animal models of colorectal and other cancers.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3546-41-6
• MW: 575.71
• Purity: 98.43%
• Formula: C₂₆H₂₈N₃ . 1/2 C₂₃H₁₄O₆
• SMILES: CN(C)c1ccc2[n+](C)c(C=Cc3cc(C)n(c3C)-c3ccccc3)ccc2c1.CN(C)c1ccc2[n+](C)c(C=Cc3cc(C)n(c3C)-c3ccccc3)ccc2c1.Oc1c(cc2ccccc2c1Cc1c(O)c(cc2ccccc12)C([O-])=O)C([O-])=O
• Target: Wnt/beta-catenin
• Solubility: DMSO:9.62 mg/mL (16.71 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.74 mM)

Bioactivity

• In Vitro:
  Pyrvinium pamoate treatment repressed the phosphorylation of GSK3β at S9 which might be mediated by AKT, and decreased the protein levels of β-catenin and its downstream targets (c-Myc, cyclin D1). Pyrvinium pamoate remarkably inhibited cell viability and colony formation ability. Treatment with pyrvinium pamoate induced intrinsic pathway-dependent apoptosis accompanied with a decline of anti-apoptotic XIAP and Survivin, and an overt increase of pro-apoptotic Bax. In addition, pyrvinium pamoate significantly inhibited the migration and invasion in vitro.

Storage & Handling

• Storage: Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, bcatenin, betacatenin, beta-catenin, Pyrvinium, Pyrvinium embonate, Pyrvinium pamoate, Wnt, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, βcatenin

Compound Identifiers

PubChem CID

54698174