Pyronaridine tetraphosphate

SKU: orb1706751

Description

Pyronaridine tetraphosphate

Research Area

Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 76748-86-2
• MW: 910.03
• Purity: 99.82%
• Formula: C₂₉H₄₄ClN₅O₁₈P₄
• SMILES: O=P(O)(O)O.ClC(C=CC1=C2NC3=CC(CN4CCCC4)=C(O)C(CN5CCCC5)=C3)=CC1=NC6=C2N=C(OC)C=C6.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O
• Target: Parasite,Topoisomerase
• Solubility: DMSO:10 mg/mL (10.99 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.1 mM);H2O:20 mg/mL (21.98 mM)

Bioactivity

• Target IC50:
  P. falciparum:1.53-3.94 nM
• In Vivo:
  Reducin the parasitic burden in Echinococcus granulosus-infected mice, pyronaridine tetraphosphate (57 mg/kg, oral administration, q.d. For 30 days) has been demonstrate. educin the parasitic burden in secondarily infected (cysts) mice, pyronaridine tetraphosphate (57 mg/kg, intraperitoneal injection, q.d. For 3 days) has shown efficac. xhibiting a higher exposure in the liver than in the plasma in Male ICR mice, pyronaridine tetraphosphate (57 mg/kg, intraperitoneal injection, for a single dose) has been observe.
• In Vitro:
  With an IC50 value of 1.53-3.94 nM, pyronaridine tetraphosphate (24 h) exhibits anti-P. falciparum activit.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pyronaridine, Pyronaridine tetraphosphate, topoisomerase II

Compound Identifiers

PubChem CID

156867