Pyrithioxin dihydrochloride

SKU: orb1705451

Description

Pyrithioxine dihydrochloride is a neuroactive compound with demonstrated anti-nociceptive and anti-allodynic properties. It enhances cerebral glucose and amino acid metabolism, making it a tool for studying neurological conditions like atherosclerosis in experimental models. Notably, it has been associated with inducing cholestatic hepatitis in research settings.

Research Area

Metabolism Research

Key Properties

• CAS Number: 10049-83-9
• MW: 441.39
• Purity: 99.92% (May vary between batches)
• Formula: C₁₆H₂₂Cl₂N₂O₄S₂
• SMILES: OC1=C(CO)C(CSSCC2=CN=C(C)C(O)=C2CO)=CN=C1C.Cl.Cl
• Target: Endogenous Metabolite
• Solubility: DMSO:50 mg/mL (113.28 mM);H2O:40 mg/mL (90.62 mM)

Bioactivity

• In Vivo:
  METHODS: The effect of Pyrithioxin dihydrochloride on children with learning disabilities was tested under strict double-blind conditions in 67 students in a class with learning disabilities aged 11 to 16 years who received either Pyrithioxin dihydrochloride (300 mg, 24 hours) or placebo for 6 months. Effects on cognitive function. RESULTS:Pyrithioxin dihydrochloride had different effects on different subjects. None of the 22 parameters showed a statistically significant treatment effect in terms of mean performance. Variability was significantly higher in the Pyrithioxin dihydrochloride group (F = 1.85-2.33, P less than 0.05 and less than 0.02, respectively).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Life, NSC 526973, NSC526973, NSC-526973, Endogenous Metabolite, EndogenousMetabolite, Vitamin B6 disulfide dihydrochloride, Pyrithioxin, Pyrithioxine HCl, Pyrithioxine hydrochloride, Pyritinol dihydrochloride

Compound Identifiers

PubChem CID

82325