pyridoxal isonicotinoyl hydrazone

SKU: orb1301897

Description

pyridoxal isonicotinoyl hydrazone

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 737-86-0
• MW: 286.29
• Purity: 99.91% (May vary between batches)
• Formula: C₁₄H₁₄N₄O₃
• SMILES: Cc1ncc(CO)c(\C=N\NC(=O)c2ccncc2)c1O
• Target: Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.49 mM);DMSO:28.63 mg/mL (100 mM)

Bioactivity

• In Vivo:
  Intraperitoneal administration of PIH to mice (5 mg/25 gm mouse/day) over 6 days decreased 59Fe levels in the liver, spleen, and kidney but not in the blood. After oral administration, PIH resulted in an eightfold increase in fecal Fe excretion and possibly some urinary excretion of Fe .
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• In Vitro:
  After a 60-minute reincubation of 59Fe-labeled reticulocytes with tris-hydroxamate deferoxamine (5 mmol/L), 3.5% of cellular 59Fe was released, although Pyridoxal isonicotinoyl hydrazone (PIH) at a 50-fold lower concentration (0.1 mmol/L) released 38.6% of cellular 59Fe . In primary human hepatocytes and the human hepatocellular carcinoma cell line HepG2/C3A, PIH treatment decreases Fech protein levels, but not Fech mRNA levels; and PIH is detected after isoniazid treatment, with levels increasing further when exogenous vitamin B6 analogs are coadministered .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

pyridoxal isonicotinoyl hydrazone, inhibit, iron, Inhibitor, PIH

Compound Identifiers

PubChem CID

135409539