Pyridostatin TFA

SKU: orb1302832

Description

Pyridostatin TFA

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 1472611-44-1
• MW: 938.71
• Purity: 97.09%
• Formula: C₃₇H₃₅F₉N₈O₁₁
• SMILES: OC(=O)C(F)(F)F.NCCOc1cc(nc(c1)C(=O)Nc1cc(OCCN)c2ccccc2n1)C(=O)Nc1cc(OCCN)c2ccccc2n1
• Target: DNA/RNA Synthesis
• Solubility: DMSO:52 mg/mL (55.4 mM)

Bioactivity

• Target IC50:
  G-quadruplexe (Cell-free assay):490 nM(Kd)
• In Vitro:
  Pyridostatin decreases the proliferation of MRC-5–SV40 cells and various cancer cell lines, and induces cell-cycle arrest by DNA-damage checkpoint activation. Pyridostatin also reduces SRC-dependent cell motility in MDA-MB-231 cells by interacting with G-quadruplex motifs in SRC.Pyridostatin decreases EBNA1 synthesis via inhibition of G-quadruplexes.
• Cell Research:
  Cell lines: MRC-5–SV40 cells and various cancer cell linesConcentrations: 10 μMIncubation Time: 48 hMethod: Cells are plated at equal confluence and are left either untreated or were treated with 2 μM pyridostatin continually during the indicated time before harvesting the cells. Cells from individual plates are trypsinized and counted in a Coulter counter. Graphs represent the total cell numbers at each time interval, and the error bars represent the s.e.m. Data represent three independent experiments.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

arrest, cycle, damage, DSB, DNASynthesis, DNA, DNA Synthesis, G-quadruplex, Inhibitor, neurodegeneration, inhibit, Pyridostatin, Pyridostatin TFA, structure, SRC, RR 82, RR82, RR-82, RNA Synthesis, RNASynthesis

Compound Identifiers

PubChem CID

117064504