Pyrantel tartrate

SKU: orb1225272

Description

Pyrantel tartrate is an antinematodal thiophene; and can elicit spastic muscle paralysis in parasitic worms due to prolonged activation of the excitatory nicotinic acetylcholine (nACh) receptors on body wall muscle.(In Vitro):Pyrantel tartrate (10 nM-10 μM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity.(In Vivo):Pyrantel tartrate (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 33401-94-4
• MW: 356.39
• Purity: >98% (HPLC)
• Formula: C₁₅H₂₀N₂O₆S
• SMILES: CN1CCCN=C1/C=C/C2=CC=CS2.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
• Target: Others
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  Pyrantel tartrate (10 mg/kg; p.o. ; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%. Animal model: Male Syrian Golden hamsters (3-week-old; A. ceylanicum-infected). Dosage: 10 mg/kg. Administration: Oral administration; single. Result: Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.
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• In Vitro:
  Pyrantel tartrate (10 nM-10 μM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity. Cell Viability Assay Cell line: A. suum Concentration: 10 nM-10 μM. Incubation time: 72 h. Result: Inhibited A. suum with a pEC50 value of 7.24.Cell Viability Assay Cell line: N. americanus Concentration: 0-168.2 M (0-100 μg/mL) Incubation time: 72 h. Result: Inhibited third-stage larvae and adult of N. americanus with IC50 values of 2.0 and 7.6 mg/mL, respectively.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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